Recent Federal Medical Research Grants in Ohio State Total $ 55.5 Million

Ohio State University’s medical research teams have received four federal awards totaling $ 55.5 million in funding in recent months.

The grants support the study of a variety of neurological disorders as well as the creation of a knowledge bank that will serve as a national resource for multidisciplinary expertise in maternal and pediatric therapeutics.

These awards came on the heels of record research funding from the Ohio State College of Medicine of the National Institutes of Health in fiscal year 2021 – $ 195 million in grants, contracts and subcontracts. In total, the college’s research funding for FY21 was $ 301.9 million, the second highest level of research funding in a fiscal year in the history of the school, remaining scholarships from other government agencies, nonprofit foundations, and industrial contracts.

“The continued growth in research funding at Ohio State University College of Medicine underscores our commitment and expertise in the investigative process that leads to pioneering biomedical discoveries,” said Carol Bradford, Dean of the College of Medicine and Vice president of health sciences at The Wexner Medical Center at Ohio State University. “It is with these essential research dollars that our faculty, staff and learners are able to translate lab results into bedside treatments.

Four multi-million dollar grants were announced in September.

A grant of $ 17.1 million over five years Fund the creation of a knowledge bank to support the study of drugs and medical treatments for pregnant and breastfeeding women and children, with the aim of filling research gaps and improving understanding of how the drugs work and interact with the bodies of these populations. The National Institute of Child Health and Human Development’s Eunice Kennedy Shriver Award for the Departments of Biomedical Informatics, Obstetrics and Gynecology, and Pediatrics will help establish the Coordinating Center for Data, Models, Knowledge and research on maternal and pediatric accuracy in treatment data.

“In addition to developing the knowledge base in pharmacology, we will coordinate research activities, promote educational opportunities and model interactions between drugs and pregnant and lactating women and their children,” said Lang Li, Principal Investigator and Professor and President of Biomedical Informatics. “Artificial intelligence and machine learning are the real innovations behind our data integration and model development. “

The National Institute of Neurological Disorders and Stroke has allocated $ 16 million for a seven-year, multi-center, Ohio-led research project that will compare inpatient rehabilitation treatments for traumatic brain injury (TCC).

The “CARE-4-TBI” project involves the Ohio Regional TBI Model System as well as 14 other TBI Model System sites across the United States that provide care and rehabilitation for brain injuries in order to to help people return home and reintegrate into their communities.

“We will determine which rehabilitation strategies work best for patients by leveraging the TBI model systems infrastructure, capturing treatment data from standardized electronic medical records, and using advanced statistical methods to compare the effectiveness of different treatment approaches, ”said lead researcher Jennifer Bogner. , professor of physical medicine and rehabilitation.

A $ 14.6 million award from the National Institute of Neurological Disorders and Stroke will accelerate Ohio State research to further evaluate the safety and effectiveness of gene therapy to treat a rare genetic condition called AADC (aromatic L-amino acid decarboxylase) deficiency, which causes severe physical and developmental impairments in children. This research will build on previous work at Ohio State and the University of California at San Francisco using the targeted delivery of gene therapy to the midbrain to treat the fatal neurodevelopmental disorder.

“Without this enzyme, children lack muscle control and are usually unable to speak, eat or even lift their heads. They also suffer from seizure-like episodes… which can last for hours, ”said lead researcher Dr Krystof Bankiewicz, professor of neurological surgery. “The delivery of a functional copy of the AADC gene would significantly reduce the suffering of affected patients and pave the way for the registration of other gene therapies for neurological diseases.”

A grant from the National Institute on Aging will support the creation of an interdisciplinary resource network for Alzheimer’s disease and related dementias. The prize, which is expected to total $ 7.8 million over five years, brings together researchers from Ohio State with clinical scientists from the University of Washington, neuroscientists from the Medical Branch of the University of Texas and structural biologists from the University of California at Los Angeles.

The project stems from the National Alzheimer’s Project Act of 2012 calling for a national plan for the prevention and treatment of Alzheimer’s disease by 2025 and stressing the importance of accelerating efforts to identify early and pre-symptomatic stages of disease at the molecular level. The resource network supports this strategy by providing researchers with the tools necessary to reliably detect the disease in experimental models and by raising the standards of rigor and reproducibility in Alzheimer’s disease research.

“By establishing the gold standard for their analysis and detection, and then distributing well-controlled samples to research laboratories across the country, we hope to catalyze progress in the diagnosis and treatment of this devastating disease,” said principal investigator Jeff Kuret, professor of biological chemistry and pharmacology.

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