Predicting seizures with devices worn on the wrist p

ROCHESTER, Minn. – Despite medications, surgery and neurostimulation devices, many people with epilepsy continue to have seizures. The unpredictable nature of seizures is severely limiting. If seizures could be reliably predicted, people with epilepsy could change their activities, take a fast-acting medication, or increase their neurostimulator to prevent a seizure or minimize its effects.

A new study in Scientific reports Researchers from the Mayo Clinic and international collaborators found that patterns could be identified in patients who wore a special wristwatch monitoring device for six to 12 months, allowing about 30 minutes of warning before a seizure. does not happen. It worked well most of the time for five of the six patients studied.

“Just as a reliable weather forecast helps people plan their activities, seizure forecasting could also help epilepsy patients adjust their plans if they knew a seizure was imminent,” said Benjamin Brinkmann, Ph .D., An epilepsy scientist at Mayo Clinic and lead author. “This study using a device worn on the wrist shows that it is possible to provide reliable predictions of seizures for people with epilepsy without directly measuring brain activity.”

In the study, patients with drug-resistant epilepsy and an implanted neurostimulation device that monitors electrical brain activity were given two wrist-worn recording devices and a tablet to upload data to cloud storage daily. . Patients had to wear one wristband while the other charged. They changed devices at a fixed time each day. They used the devices while participating in their normal activities, providing unique long-term data for the study.

Information gathered from the wearable device included electrical characteristics of the skin, body temperature, blood flow, heart rate, and accelerometry data that tracks movement. The data was analyzed with an artificial intelligence deep learning neural network approach, using an algorithm for time series and frequency analysis. Since the research participants already had a deep brain stimulation device implanted to treat their epilepsy, these neurostimulation devices were used to confirm seizures, allowing the team to measure the accuracy of the devices’ predictions. worn on the wrist.

While the ability to predict seizures has already been demonstrated using implanted brain devices, many patients do not want an invasive implant, notes Dr. Brinkmann.

“We hope that this research with portable devices will pave the way for integrating seizure prediction into clinical practice in the future,” said Dr Brinkmann, noting that this was a preliminary study. and that other patients register data to expand this test.

The other authors are Mona Nasseri, Ph.D., Mayo Clinic and University of North Florida; Tal Pal Attia, Mayo Clinic; Boney Joseph, MBBS, Mayo Clinic; Nicholas Gregg, MD, Mayo Clinic; Ewan Nurse, Ph.D., Seer Medical; Pedro Viana, King’s College London; Gregory Worrell, MD, Ph.D., Mayo Clinic; Matthias Dumpelmann, Ph.D., University of Freiberg; Mark Richardson, Ph.D., King’s College; and Dean Freestone, Ph.D., Seer Medical.

This study is part of the Epilepsy Foundation of America’s Epilepsy Innovation Institute and the My Seizure Gauge project, which is an international collaboration aimed at using wearable devices for the detection and prediction of epileptic seizures. Additional support was provided by the Mayo Clinic’s Neurology Artificial Intelligence Program.

Dr Brinkmann received non-financial research support from Medtronic and licensed the intellectual property to Cadence Neuroscience Inc.

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About the Mayo Clinic
Mayo Clinic is a non-profit organization committed to innovation in clinical practice, education, and research, and providing compassion, expertise, and answers to all in need of healing. Visit the Mayo Clinic News Network for more information on the Mayo Clinic. For more information on COVID-19, including the Mayo Clinic Coronavirus Map Tracker, which has 14-day forecasts of COVID-19 trends, visit the COVID-19 Resource Center at the Mayo Clinic.

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