Epilepsy – Kepplah http://kepplah.com/ Wed, 29 Jun 2022 08:25:55 +0000 en-US hourly 1 https://wordpress.org/?v=5.9.3 https://kepplah.com/wp-content/uploads/2021/05/kepplah-150x150.png Epilepsy – Kepplah http://kepplah.com/ 32 32 Role of a single gene linked to epilepsy, autism identified: study https://kepplah.com/role-of-a-single-gene-linked-to-epilepsy-autism-identified-study/ Wed, 29 Jun 2022 08:25:55 +0000 https://kepplah.com/role-of-a-single-gene-linked-to-epilepsy-autism-identified-study/

A single gene that was previously shown to be the driving force behind a rare syndrome linked to epilepsy, autism and developmental disabilities has been identified as central to the formation of healthy neurons.

Researchers say the gene, DDX3X, forms a cellular machine called helicase, whose job is to open the hairpins and dead ends of RNA so that its code can be read by the machinery for making cell proteins.

Duke researchers say the gene, DDX3X, forms a cellular machine called helicase, whose job is to open the hairpins and dead ends of RNA so that its code can be read by the machinery of production of cell proteins. This gene is carried on the X chromosome, so females have two copies of the gene and males have only one.

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“If you delete both copies of the gene in a female mouse, it results in massive microcephaly where brain size is dramatically reduced,” said Debra Silver, PhD, associate professor of molecular genetics and microbiology at Duke School of Medicine. . who led the research team. “But the deletion of a single copy probably more closely mimics what happens in human patients,” Silver said.

In other words, the defects caused by defective DDX3X are dose-dependent – ​​the syndrome can vary depending on how severe the helicase production affected by the mutations is. The results appear June 28 in the open-access journal eLife.

When DDX3X is altered by a mutation early in development, “you don’t get as many neurons over time because this gene is necessary for the production of neurons from progenitor cells,” Silver said. “And it also helps the progenitors divide properly.”

While it normally takes about 15 hours for a nerve precursor cell to divide, mutated DDX3X can make that process even longer, Silver said. “And what that means over time, if those neural precursors take too long to divide, you’re falling behind and the brain isn’t developing properly.”

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In a previous study published by the team in March 2020, using genetic samples from 107 children with developmental disabilities from around the world, researchers found that half of DDX3X mutations completely disrupt the gene, but the other half only made it work worse.

DDX3X mutations are now thought to cause 1-3% of intellectual disabilities in women, but the mutations are almost always “de novo”, meaning they occurred spontaneously during some developmental phase. , rather than being inherited from parents.

The children in the previous study were almost all female, leading researchers to speculate that loss of DDX3X in males would be fatal, as they carry only one copy of the gene. But in this work, Silver’s team discovered that a companion gene carried by the male Y chromosome, DDX3Y, may perform part of the gene’s function.

To do this work, Silver’s lab, led by Mariah Hoye, developed a novel approach to profiling all newly made proteins from progenitor cells in the brain of a living animal, a technique that could lead to an important understanding of the protein synthesis in the brain, she said.

Some of the RNAs whose translation is reduced by damage to DDX3X also play a role in brain development, Silver said. “So that’s helping us uncover what I would call an RNA network that depends on this gene for translation. And that’s starting to give us clues as to how, at the molecular level, DDX3X can disrupt brain development. “

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DDX3X has also been implicated in neurodegeneration, the progression of certain cancers, and innate immune responses. Silver said understanding the cellular processes and molecular targets of DDX3X in the developing brain could help shed light on the basis of many disorders.

“We know of over 800 families worldwide who have been diagnosed with DDX3X syndrome,” Silver said. “This is definitely an important gene, with probably hundreds of mutations. There really is a lot to learn about how DDX3X controls brain development.”

“We hope this research can improve understanding of the basis of DDX3X syndrome and associated disorders,” Silver said. “In the longer term, this may contribute to the development of therapies.”

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England appoints first-ever Women’s Health Ambassador – here’s what she should focus on https://kepplah.com/england-appoints-first-ever-womens-health-ambassador-heres-what-she-should-focus-on/ Mon, 27 Jun 2022 15:35:07 +0000 https://kepplah.com/england-appoints-first-ever-womens-health-ambassador-heres-what-she-should-focus-on/

The government recently appointed Dame Lesley Regan, professor of obstetrics and gynecology at Imperial College London, as England’s first Women’s Health Ambassador. The new role was created to help close the gender gap in health.

Women make up 51% of the population in England and Wales, but persistent gender-based inequalities in health, social protection, living standards and employment mean that women spend more years than unhealthy men. And for the first time in a century, their life expectancy is falling – and women in deprived neighborhoods are the most affected.

Women from underserved and underrepresented racial and ethnic groups face consistently poor outcomes, even after controlling for socioeconomic factors. Black mothers are four times more likely to die during pregnancy and childbirth than white mothers.

Timely, inclusive and relevant research based on woman-centred care is essential to addressing the above issues. Regan stressed the immediate need to focus on areas that affect almost all women – like menopause, menstrual issues and contraception. She also stressed the importance of empowering women to access the health care they need throughout their lives.

throughout life

Women’s health should be considered across the lifespan. For example, conditions such as polycystic ovary syndrome have different symptoms at different stages of a woman’s life. Menstrual irregularities and facial hair are common in adolescence, but other symptoms – such as infertility, diabetes during pregnancy and even complications such as high blood pressure and type 2 diabetes, accidents strokes and heart attacks – are common in the long term. A single strategy targeting polycystic ovary syndrome throughout a woman’s life will have a positive effect on her health in the short and long term.

Another important area that needs more attention is pregnancy in women with underlying complications, such as epilepsy. Compared to over 200 randomized trials involving the general population with epilepsy, there is only one trial involving pregnant women. Despite improved maternity care, maternal deaths are increasing among women with epilepsy, primarily because the risks of seizures during pregnancy are not properly identified.



Read more: Research on pregnancy, childbirth and infant care is historically underfunded – and women are paying the price


Effective communication of risks, benefits and treatments during pregnancy is an essential component of woman-centred care. The recent Cumberlege review of complications in babies exposed to the drug valproate (an epilepsy drug) during pregnancy highlights the lack of communication with women about the risks. In order for women to make informed decisions about the treatments offered to them, they need reliable information on the long-term effect of the drugs taken during pregnancy.

Pregnancy and lactation should not be grounds for excluding women from drug trials. The recent Safe and Effective Medicines for Use in Pregnancy report outlines how research can be managed to alleviate safety concerns and build confidence in women and their doctors.

Racial and ethnic disparities

To optimize the health of all women, we must address disparities in health outcomes stemming from racial, ethnic and socioeconomic factors. The first step is to really understand the burden of the problem faced by women in different regions and for specific conditions, and to provide targeted funding. We need to identify women at risk of poor health early and target interventions to prevent complications. Additionally, pregnancy complications negatively affect babies in the long run. This intergenerational impact can further aggravate inequalities related to race and ethnicity.

It will also be important to invest more in research that promotes women’s health. This can be achieved by building on UK academic expertise, investing more in these areas, building infrastructure within the NHS and providing training opportunities for early career researchers and clinicians. The seamless integration of academic and health services is essential to successful research.

Any effort to improve women’s health can only be successful if women and their families are involved from start to finish in research. Women must guide, support, direct and disseminate research. We need dedicated, inclusive and representative patient and public groups to promote women’s health research.

The appointment of a dedicated Women’s Health Ambassador is the first step towards achieving the ambitious goal of eliminating health inequalities based on gender, race and income for the benefit of all women and generations. future.

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36-Year-Old Epileptic Technician Tells How He Lost Both Legs: Now He’s Running a Marathon With Prosthetics https://kepplah.com/36-year-old-epileptic-technician-tells-how-he-lost-both-legs-now-hes-running-a-marathon-with-prosthetics/ Sun, 26 Jun 2022 00:26:39 +0000 https://kepplah.com/36-year-old-epileptic-technician-tells-how-he-lost-both-legs-now-hes-running-a-marathon-with-prosthetics/

A man who lost both his legs after suffering a seizure and falling on a New York City subway platform plans to compete in a 5k obstacle course and a 6k race this weekend after training with prosthetic legs for a year.

Roman Leykin, 36, a former technician from Brooklyn who was diagnosed with epilepsy as a teenager, suffered a seizure on his way to work in February 2018, the Stamford Advocate reported.

The sudden attack caused him to fall onto subway tracks as a train ran over him, leaving him with a traumatic brain injury and his legs needing to be amputated.

No longer able to do his job, Leykin took to the world of athletics, taking on the Gaylord Guantlet 5K obstacle course on Saturday and the Achilles Hope & Possibility 6K on Sunday.

“Right now I’m going to as many amputee events as I can across the country and soon around the world,” Leykin told the attorney. “I can not stop.”

Roman Leykin, 36, suffered a traumatic brain injury and had both legs amputated after being hit by a New York City subway train in 2018. Forced to quit his job in tech, Leykin moved on to master walking with his new prostheses in one year.

Leykin walking around last week with his 'tech legs'

Leykin has come a long way after first falling with the legs when he tried them for the first time last year

Leykin (above) is confident in his ability to walk with the new prostheses as he competed in a 5km obstacle course on Saturday and plans to complete a 6km run on Sunday.

Leykin, who was a web developer working in Manhattan, said the moments after his 2018 accident were hazy after he fell unconscious with the brain injury he suffered.

He spent a year at Burke Rehabilitation Hospital in White Plains, New York, and used a wheelchair until 2021.

It was a big year for Leykin, who made a commitment to walk with short prostheses.

“I jumped out of my wheelchair and took a few steps and fell down immediately,” Leykin told the attorney of his first attempt with the “stubbies.”

‘I got up straight away. And I fell. And I immediately got up. And I fell.

“And within 15 or 20 minutes I was walking without clinging to a single thing. Yes, I was smaller, but freedom of movement gave me the freedom to live.

Documenting his progress on Instagram and TikTok, where he has nearly 200,000 followers, Leykin can be seen taking short, awkward strides in May 2021 before dropping with a smile on his face about freedom of mobility.

Since then, Leykin has evolved to use longer “technical legs” as he enjoys hiking, sailing, golf, bowling, rock climbing, hockey, skiing and other sports.

“I am a very competitive person. I love to sweat. So doing anything that makes you sweat makes me feel good, whatever the activity,” he said.

Leykin spent a year recovering from his accident and is now committed to training his body

Leykin spent a year recovering from his accident and is now committed to training his body

He's done a plethora of different sports, including rock climbing earlier this year.

He’s done a plethora of different sports, including rock climbing earlier this year.

With his new prosthetic long legs, Leykin has also taken up cycling

With his new prosthetic long legs, Leykin has also taken up cycling

Leykin’s last venture was the chaotic Gaylord Gauntlet, a charity obstacle course run by Gaylord Specialty Healthcare at their Wallingford campus.

The 5K event features hikes through forest and mud hills, obstacles over trees and walls, and a slide in a pool of water. Overall, the race featured 24 hurdles for Leykin and others to overcome.

Katie Joly, program manager for the Gaylord Sports Association, praised Leykin for her drive and ability to change her life.

“A lot of times people get that confidence back to be who they are again because … a lot of the people we work with have had spinal cord injury, stroke, traumatic brain injury, limb loss, like Rome, and they learn to live their lives differently,” Joly told the lawyer.

The Gaylord Gauntlet featured 24 obstacles for Leykin and others to overcome

The Gaylord Gauntlet featured 24 obstacles for Leykin and others to overcome

Obstacles include a wall climb after hiking through mud hills

Obstacles include a wall climb after hiking through mud hills

The penultimate obstacle is a slippery slope in a pit of water

The penultimate obstacle is a slippery slope in a pit of water

The fun but grueling course would leave most people too sore to move the next day, but Leykin opted to tackle the 20th annual Achilles Hope & Possibility four-mile race on Sunday instead.

The race, which is set to start in the morning in New York’s Central Park, celebrates the inclusion of people with disabilities and allows everyone to join the event on the heels of the anniversary of the signing of the Americans with Disabilities Act .

Leykin told the attorney he was excited to be in the race and keen to follow his mantra, “Relentless Positive Momentum.”

The athlete said he was still moving forward, jokingly warning others: “I’m not going to get in your way, but don’t you dare get into mine because… you might get knocked down, you might get stepped on on, you could run you over.’

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Houston’s first medical marijuana dispensary is now open in The Heights. So how do you qualify? https://kepplah.com/houstons-first-medical-marijuana-dispensary-is-now-open-in-the-heights-so-how-do-you-qualify/ Thu, 23 Jun 2022 22:56:11 +0000 https://kepplah.com/houstons-first-medical-marijuana-dispensary-is-now-open-in-the-heights-so-how-do-you-qualify/

Texas legalized medical marijuana for certain patients years ago, but only on a very restricted basis.

Jeff Chiu, STF/Associated Press

Houston is finally home to a legal weed dispensary, but don’t get too excited just yet — it’s restricted to people with medical prescriptions, which can only be given to people with specific ailments. So who can get a prescription?

Texas Original, a chain of medical marijuana dispensaries across Texas, opened this week at 1714 Houston Ave., offering people with prescriptions an easier way to get a range of legal marijuana products, according to Evan MacDonald of ReNew Houston. The business is the first of its kind in the city of Bayou and the first Texas Original storefront open five days a week, offering next day pickup for customers.

The dispensary is strictly for those authorized under the Lone Star State’s Compassionate Use Program, which requires a diagnosis of a certain disease or condition and a prescription from a physician. The law currently only allows prescriptions for a handful of medical conditions, including: ALS, Alzheimer’s disease, autism, epilepsy, multiple sclerosis, Parkinson’s disease, Huntington’s disease, chronic traumatic encephalopathy, cancer or post-traumatic stress disorder.

There were deliberations in the Texas Legislature last year about adding chronic pain sufferers to the list, but the measure fell through. To complicate matters further, the law only allows low-THC cannabis prescriptions. THC, or tetrahydrocannabinol, is the main psychoactive ingredient in marijuana. The state currently only allows cannabis products that contain 1% or less THC.

The state of Texas requires a specialist to confirm the diagnosis, which means your primary care physician likely won’t be able to complete the script. In addition, a second doctor is needed to corroborate the first specialist’s diagnosis. Both must also be on the Texas State Compassionate Use Registry. According to Timothy Fanning of the San Antonio Express-News, there are currently fewer than 200 doctors certified to write such prescriptions statewide.

The state hosts this online directory to help you find a doctor licensed to help with a diagnosis and obtain a prescription. There are dozens of them in Houston.



]]> Kentucky Medical Marijuana Meetings Underway https://kepplah.com/kentucky-medical-marijuana-meetings-underway/ Tue, 21 Jun 2022 23:55:00 +0000 https://kepplah.com/kentucky-medical-marijuana-meetings-underway/

KENTUCKY (WFIE) — Team Kentucky’s medical cannabis advisory committee held its first meeting in Frankfurt on Monday.

Two people from the three states are part of this committee.

Julie Cantwell is one of the Kentucky team’s medical cannabis advisory committee members and says she’s a lawyer herself, for reasons close to her.

“My son, Preston, he has generalized epilepsy. He has drug-resistant epilepsy,” Cantwell explains, “so about 3 years ago we decided to let him use medical cannabis from outside of the state, and he hasn’t had a seizure for 32 months.”

“People in their 70s and 80s are crossing state lines for help, and it makes me really sad that people have to break the law for something that really really works,” Cantwell says.

Cantwell is joined by 16 other specially selected members who will take the time to listen to Kentuckians across the state, both for and against the legalization of medical marijuana, to advise the administration on how to go about.

They will hear from residents like Grace Henderson, who says she has treated more than 20 chronic conditions in the past.

“I was diagnosed with Chron’s disease in 2005, my freshman year of college, and by then I had already been managing chronic pain for many years,” says Henderson.

Henderson says she was so debilitated by her ailments that she was placed on disability in 2011. She says she could barely function, let alone hold down a job.

She was tired of going through prescription drugs, hoping to find relief.

She’s switched to cannabis-related products, and she says it’s helped her tremendously.

In 2019, she was even able to get out of the handicap.

“I was able to find a job and use my college education, you know what I mean?” says Henderson, “like, all these student loans, I’m able to put all of that to good use, just by using cannabinoids and cannabis products.”

The problem?

The products that Henderson and Cantwell’s son each used came from out of state and are currently illegal in Kentucky. This is what the board is considering changing.

“They’re just ready for the state to do the right thing and legalize this,” Cantwell says.

“I won’t be considered a criminal anymore, and people like me won’t be considered criminals anymore, because I’m not a criminal,” Henderson said.

The committee will hold forums on July 6 in Pikeville, then on July 19, again in Frankfort.

The Kentucky team commentary page can be found here.

The Kentucky Moms for Medical Cannabis page can be found here.

Copyright 2022 WFIE. All rights reserved.

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Cotard delirium and schizophrenia: signs and treatment https://kepplah.com/cotard-delirium-and-schizophrenia-signs-and-treatment/ Mon, 20 Jun 2022 12:29:08 +0000 https://kepplah.com/cotard-delirium-and-schizophrenia-signs-and-treatment/

Cotard’s delirium, or Cotard’s syndrome, occurs when a person believes that they are dead, that they do not exist, that they have missing body parts or body parts that are disappearing. It is a rare and serious syndrome that can signify schizophrenia. However, other conditions can also cause Cotard syndrome.

It is not always true that a person with Cotard syndrome has schizophrenia. Many conditions can cause Cotard syndrome, and some people experience it as a short-lived symptom after a seizure.

Some scientists believe Cotard’s syndrome may be related to lesions in the non-dominant hemisphere of the brain. It is the side of the brain that is on the same side of the body as a person’s dominant hand. However, a series of factors can influence its development.

This article takes a closer look at Cotard syndrome and schizophrenia, including their relationship, signs and symptoms, and treatment.

Cotard’s delirium, or Cotard’s syndrome, is a rare and serious change in a person’s perception of their body or their existence. It encompasses a group of false but strong beliefs that can vary in nature.

For example, some people with this syndrome may believe they are dead, while others may believe they are immortal.

Delusions are different from unusual or mistaken beliefs. A person with Cotard syndrome is convinced that their perceptions are true, even when the evidence points to the contrary.

This can cause them to engage in behaviors they otherwise wouldn’t. For example, a person who believes they are dead may stop eating.

Other names for Cotard syndrome include “walking corpse syndrome” or nihilistic delirium.

Learn more about delusional disorder here.

The main symptom of Cotard syndrome is a false belief about a person’s existence. They may believe that:

  • They do not exist
  • they are dying or dead
  • some parts of their body are missing
  • they are immortal, or that they died and started a new life

People with this syndrome may also believe that their organs are falling apart, disappearing, or being eaten.

A 2017 review found that 8 of 12 people identified as having Cotard syndrome believed they had died. Of these, three believed medical professionals had killed them. Four said they were dying.

Learn more about types of schizophrenia here.

Yes, Cotard’s delirium can be a symptom of schizophrenia. However, it is rare. A 2021 article reports that less than 1% of people with schizophrenia have it. A person does not need to have this syndrome to be diagnosed with schizophrenia.

Schizophrenia is a recognized cause of Cotard syndrome. The small 2017 review of 12 people with Cotard syndrome found that two also had schizophrenia.

People with schizophrenia, bipolar disorder, and other mental health issues may experience one or types of delusionsincluding:

  • delusions of grandeur, which is the belief that a person is powerful, special, or more important than others.
  • delusions of persecution, which is when a person mistakenly believes that someone or something is trying to hurt them
  • delusions of misidentification, which is the false belief that two people or places have changed places
  • religious delusions, which is when a person believes they are a god or god-like entity
  • erotomaniac delusions, which is when a person believes that someone, such as a celebrity, is in love with them

Learn more about the myths and truths about schizophrenia here.

Researchers don’t quite understand what causes Cotard syndrome or why it can occur in people with schizophrenia.

Cotard syndrome is a rare diagnosis and most people with conditions that may cause it never develop it. This may mean that a combination of biological, psychological, social and environmental factors play a role.

Researchers have found that people with Cotard syndrome tend to have changes in their brains, suggesting that underlying neurological issues may play a role in its development. For example, the 2018 article of 12 people with Cotard syndrome found that:

  • four people had changes to the frontal lobe of the brain
  • four had generalized loss of brain volume
  • five showed signs of reduced blood flow to certain areas of the brain
  • seven had lesions on at least one side of the brain

Eight of the participants had a history of psychiatric diagnoses, such as schizophrenia, depression or substance abuse. Five also had neurological symptoms.

Some of the conditions that can increase the risk of Cotard syndrome include:

  • Epilepsy: A person may have delusions because of brain damage related to epilepsy or in the post-seizure period.
  • Neurological diseases: Conditions that cause brain damage, such as dementia, stroke, and traumatic brain injury (TBI), can cause delusions.
  • Substance abuse: A person can develop delusions under the influence of drugs or due to drug-related brain damage.
  • Psychiatric conditions: Mental health disorders such as depression often occur in people with Cotard syndrome.
  • Infections: Infections, especially in the brain, can cause delusions and other neurological symptoms.

Learn about the link between depression and substance abuse here.

Doctors can usually identify Cotard syndrome by talking with a person about how they feel. However, since this syndrome is a symptom of an underlying disease, they will also need to identify the cause.

If a doctor suspects a person may have schizophrenia, they may recommend a psychiatric evaluation. It involves answering a series of questions that tell a mental health specialist about a person’s mental state.

To be diagnosed with schizophrenia, a person must meet certain criteria. The Diagnostic and Statistical Manual of Mental Disorders (DSM-V) states that a person may have schizophrenia if they experience two or more of the following symptoms for a significant duration within 1 month:

  • delusions
  • hallucinations
  • disorganized speech
  • disorganized or catatonic behavior
  • reduce emotional expression or avolition, which is a complete lack of motivation

At least one of the symptoms must be delusions, hallucinations, or disorganized speech, and they must have a significant negative impact on a person’s ability to function in various aspects of life.

If the cause is not schizophrenia, doctors may recommend:

  • blood tests to check for infections
  • brain imaging scans to look for damage in the brain
  • drug testing

Learn more about hallucinations here.

Because various conditions can cause Cotard’s delirium, there is no single treatment that will treat all cases. Instead, doctors treat the underlying cause. Depending on the underlying cause, treatment may involve:

Another potential treatment is electroconvulsive therapy (ECT), which delivers an electric shock to the brain. It can alter neurotransmitters and brain function, which can improve symptoms for some.

Learn more about ECT, including its benefits and risks.

A person should see a doctor if they think they are dead, dying, or have a missing part of their body, as this could signify a delusion.

If a loved one shows signs of delirium, offer them support and compassion. Don’t try to argue or persuade them that they’re wrong, as that won’t change their minds. Instead, suggest he see a doctor and offer to go with him.

Some people with Cotard’s delirium may believe that they no longer have to take care of themselves.

A person needs emergency care if they engage in behavior that could hurt themselves or others, such as:

  • jump off buildings or bridges
  • do not eat or drink
  • threatening to harm oneself
  • violence or aggression

If any of the above situations occur, call 911 or the nearest emergency service number.

Cotard’s delirium, or Cotard’s syndrome, occurs when a person believes they are dead, dying, or immortal. They may also believe that parts of their body are missing or missing. For example, they may think that a virus is destroying their organs.

Cotard syndrome is rare, including in people with schizophrenia. However, among people with the syndrome, schizophrenia is one of the potential causes. People with schizophrenia can have different types of delusions.

Other potential causes of Cotard syndrome include neurological conditions, such as epilepsy, drug abuse, dementia, and brain infections. Therefore, it is essential that people with this syndrome seek treatment so that a doctor can identify and treat the cause.

Learn more about mental health issues in our dedicated hub.

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4-year-old boy turns into the Hulk to quell his fears of medical intervention in Beaumont Royal Oak https://kepplah.com/4-year-old-boy-turns-into-the-hulk-to-quell-his-fears-of-medical-intervention-in-beaumont-royal-oak/ Sat, 18 Jun 2022 12:34:29 +0000 https://kepplah.com/4-year-old-boy-turns-into-the-hulk-to-quell-his-fears-of-medical-intervention-in-beaumont-royal-oak/

ROYAL OAK, Mich. – A 4-year-old boy who was due for a medical procedure at Beaumont Hospital, Royal Oak, transformed into the Hulk to quell his fears.

Joey Owen needed an electroencephalogram (EEG), a test that detects brain wave abnormalities.

“He was in character from start to finish,” said Jimmy Najia, a licensed EEG technician in the clinical neurophysiology department. “He walked in the door with his hands up as the Hulk and that’s how he left.”

Joey Owen has had seizures since he was just six months old. When he was two, he was diagnosed with benign infantile focal epilepsy, a genetic epileptic syndrome that flares up during sleep.

“He’s had about six EEGs in his life,” Joey’s mother, Rebecca Owen of Taylor, said. “Because he was so small when they started, he was completely traumatized. He got to the level where he should be wrapped up like a burrito and held down. He was screaming and crying until he fell asleep so much he was exasperated.

A d

Before this procedure, he decided to dress up as the Hulk to combat his fears.


‘I’m the Hulk, mum. We have this’


“Right before his last intervention, he was really scared, so he asked me if he could dress up as the Hulk so he could be brave like him,” Rebecca Owen said. “He had his costume in the car the whole way.”

Joey Owen (Owen family)

Joey Owen said, “I’m the Hulk, mom. We understood”, before entering the hospital.

“I can’t even explain how I felt because the past times I had to wear it crying,” Rebecca Owen said. “For him, going in alone was a big problem. He was going to go out there and be the bravest this time.

Joey Owen took his Spiderman doll, spiderman blanket, and other Marvel friends with him.

“This mother has been watching her son have seizures since he was six months old and seeing him for the first time not crying: it’s essential,” said Jenny Gordon, head of Neurodiagnostics.

Rebecca Owen said the EEG technicians, Jimmy Najia and Ivana Gavran-Danilyuk, who worked with him, were compassionate.

A d

“It was so funny for him when they were like, ‘Come on, Hulk,'” Rebecca Owen said. “They got down to his level like a pediatric ward should and just accepted him as the Hulk.”

Joey Owen has been seizure-free for two years, but must continue to have EEGs every 6 months to a year. His mother said Hulk would be back for his next date.

“Joey showed us all that no matter what life throws at us, we all have the ability to be brave,” Gordon said. “We should all be little Joeys. If he could do it, we certainly can.

Lily: More community coverage

Copyright 2022 by WDIV ClickOnDetroit – All Rights Reserved.

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Vital signs: what causes epilepsy and what treatments are available? | Health https://kepplah.com/vital-signs-what-causes-epilepsy-and-what-treatments-are-available-health/ Wed, 15 Jun 2022 23:02:00 +0000 https://kepplah.com/vital-signs-what-causes-epilepsy-and-what-treatments-are-available-health/

About 3.4 million Americans – including about 470,000 children – have epilepsy, according to the US Centers for Disease Control and Prevention. People with epilepsy have spontaneous seizures, which feel like an electrical storm in the brain.

Causes of epilepsy include brain damage, infections, tumors, and strokes. And although it has long been suspected that genetics contribute to epilepsy, until recently we were often unable to identify specific genetic disorders. Most often, the genetic changes that cause epilepsy affect how brain cells work or communicate, causing abnormal electricity in the brain. While some genetic epilepsies run in families or are hereditary, many are spontaneous or “de novo” changes occurring in families without any relatives with epilepsy. For some patients, we can identify a specific genetic cause via a test (usually blood or saliva).

The most common type of seizure caused by epilepsy is a full-body convulsion with stiffness, tremors, loss of consciousness, and breathing changes. Other types of seizures can include unresponsiveness, sensory changes such as a strange smell or taste. While people can have more than one type of seizure, most people tend to have the same type of seizure each time.

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Primary care physicians often refer children with these or similar symptoms to a neurologist to determine if a seizure has occurred. After taking a detailed history and doing a physical exam, the neurologist may give a patient brain imaging or an electrocephalogram (EEG), which examines electrical brain waves. In children and adults who continue to have seizures despite treatment with two anticonvulsant drugs, they should be evaluated by an epileptologist, a neurologist with additional training in epilepsy, at a comprehensive epilepsy center.

Medications are the first choice of treatment for epilepsy. More than 30 drugs are used to treat seizures, but the choice of which drug to try first is individualized for each patient.

My treatment goal is to stop the seizures without medication side effects. Although many people respond well to their first or second medication, a third of people with epilepsy continue to have seizures. In these patients, we consider alternative treatments such as medically supervised dietary changes (ketogenic diet or modified Atkins diet) or devices such as vagus nerve stimulators that send electrical impulses to the brain to prevent seizures. For some patients, epilepsy surgery is an option that can safely cure their seizures.

Some of the medications we use for seizures have been around for many years, but fortunately new medications and treatment options are coming out all the time.

At UVa Health, we are certified as a Level 4 center – the highest level of care – by the National Association of Epilepsy Centers, providing high quality care for children and adults. Our comprehensive care team includes neurologists and epileptologists, nurse coordinators, EEG technologists, neuropsychologists, dietitian, neuroradiologists and neurosurgeons. At UVa, I am fortunate to have phenomenal colleagues in developmental pediatrics, genetics, behavioral health, and psychiatry whom I often call on to help me care for my patients.

For more information about epilepsy care at UVa Health, visit uvahealth.com/services/epilepsy.

Dr. Erika Axeen is a neurologist at UVa Health and UVa Children’s and specializes in the assessment and management of seizures and epilepsy in children.

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Tales of woe on epileptic power supply, high tariff https://kepplah.com/tales-of-woe-on-epileptic-power-supply-high-tariff/ Tue, 14 Jun 2022 05:52:55 +0000 https://kepplah.com/tales-of-woe-on-epileptic-power-supply-high-tariff/

Poor electricity generation and supply continued to draw condemnation from electricity consumers, reports SUCCESS NWOGU

The epileptic power supply and rising electricity tariff has triggered hardship and economic loss for Nigerians. The Manufacturers Association of Nigeria and the Independent Petroleum Marketers Association, among other groups and individuals, have denounced the resulting losses. For example, the weekend before last, parts of the country were plunged into darkness following a power outage..

IPMAN losses

Responding to the decline in electricity supply, Chairman of IPMAN, NNPC Depot Ore, Western Zone of Nigeria, Shina Amao, an engineer, said traders had suffered huge losses due to electrical epilepsy . He also deplored that electricity consumers are forced to pay for services they do not benefit from. Amao said, “It definitely has a negative impact on businesses. Many of us run on generators. This eats away at our profits deeply and as such we make no profit. The government does not give us volumes. We buy products from private depots at their price and not at the official price. “By doing so, we weren’t making much profit when the power supply was low. Now that it’s erratic, it’s worse. We use diesel and gasoline to run our generators to distribute our products to people.These increase our cost in the expense area and cause our staff to be laid off when we can’t make a profit.Some customers also become victims, when they buy more fuel, you see them complaining.

Corruption

“Government interventions in the electricity sector will only work when we are able to eliminate corruption from the system. Any intervention or solution will work if we eliminate corruption. Look at the issue of refineries in Nigeria, we have repaired and maintained our refineries and we are still spending so much money that we could have set up a new refinery. So we always talk about the issue of corruption. “The erratic power supply is detrimental to business productivity, growth and sustainability. If our profit happens to be 100%, we lose almost 60% of the available profit to electricity by using generators, buying diesel and gasoline. We are spending so much and the government is not helping us by not making the product available. We always buy products from third parties and private depots that sell for high prices and they will always tell us that is the price they can sell. We always let them know that the government has not raised the price. We buy from them from depot N158 and we always pay other expenses such as transport costs. We don’t make a profit. What little profit is taken away by other costs such as the cost of energy – diesel and gasoline.

Cost of doing business

In addition, the National Chairman, IPMAN, Alhaji Debo Ahmed, denounced the negative consequences of a reduction in electricity supply. He said this definitely affects the operations of IPMAN members, adding that when there is no electricity, the demand for stations using a diesel generator becomes very high. He added that diesel-powered stations need to power their equipment and sell gasoline to the burgeoning population. According to him, “it really affects most of our traders because if there is no electricity, they have to look for an alternative, which is diesel or petrol. And the high cost of operation is quite another thing. It’s all on the high side now, so it’s really affecting our marketers. »

MAN mourns losses

MAN Managing Director Mr Segun Ajayi-Kadir said Nigerian manufacturers spent more than N72 billion on alternative energy in 2021 following power outages. He lamented that the 72 billion naira had retarded their propensity for profit, job and wealth creation as well as their competitiveness. According to him, this non-competitiveness along with other challenges has delayed the propensity of manufacturers to enter the $1.3 billion continental market across 54 countries in Africa under the African Continental Free Trade Area (AfCFTA). ). The AfCFTA is a free trade area founded in 2018, with trade beginning on January 1, 2021. The AfCFTA was established by the African Continental Free Trade Agreement between 54 of the 55 countries of the African Union. The free trade area would be the largest in the world in terms of the number of participating countries since the establishment of the World Trade Organization. The agreement was brokered by the African Union. It was signed by 44 of its 55 member states in Kigali, Rwanda on March 21, 2018. The agreement initially requires members to remove tariffs on 90% of goods, allowing free access to basic goods , goods and services across the continent. The United Nations Economic Commission for Africa (UNECA) has estimated that the agreement will boost intra-African trade by 52% by 2022. The AfCFTA aims to accelerate intra-African trade and strengthen the trade position of Africa in the global marketplace by strengthening a common voice and political space in global trade negotiations. The Managing Director of MAN urged the Federal Government to boost the competitiveness of Nigerian manufacturers by increasing power generation and distribution.

FG Explanation

Explaining the reason for this, the Federal Ministry of Energy said the sharp drop in power generation in Nigeria seen over the penultimate weekend was due to a partial shutdown of the Obengas power plant in the Edo State. The Energy Minister’s special assistant on the media, Mallam Sanusi, explained that the Obengas plant had been closed for the repair of critical gas processing equipment. The ministry said the plant shutdown occurred while other gas sources are undergoing maintenance and capacity testing. He assured consumers that concerted efforts were being made to ensure the improvement of electricity generation and supply across the country. He pleaded for consumer understanding in the face of the current challenge.

TCN’s position

The Transmission Company of Nigeria (TCN) later explained that power generation rebounded on Sunday, June 5, 2022, after a significant decline recorded on Saturday. He said production improved by 12.9% on Sunday to 70,943.35 MWh from 62,837.51 MWh recorded on Saturday. TCN also said energy supply rose 12.9% to 69,886.65 MWh from 61,910.44 MWh recorded on Saturday. Electricity production and supply had fallen 15.7% on Saturday, falling to their lowest levels since April 9, 2022. In addition, the average energy production of 76,983.67 MWh between May 29 and on June 4, 2022, lower than the average of 86,336.55 MWh recorded in the previous week. The analyst observed that Nigeria’s power generation and supply fell further below the minimum of 105,000 MWh required to register some level of stability in power supply in the country.

Rate

A Lagos resident, Mr Declan Ikenna, lamented that there had been an increase in the electricity tariff, pointing out that he was charged N30,091.43 in May 2021 but charged N34,572 in May 2022. He noted that the fare increase was surprising as it did not match the supply. On Thursday, May 5, 2022, it was reported that NERC had approved that six electric distribution companies (DisCos) should increase their electricity rates. According to a document published on December 29, 2021 and signed by Sanusi Garba, President of NERC, and Musiliu Oseni, Vice President, the new tariff came into effect from February 2022. The increase would have been contained in the data presented by NERC in the 2022 Multi-Year Rate Order (MYTO) for certain distribution companies. The revision of tariffs would concern all categories of customers. In addition, customers in main demand areas were asked to pay N60.12 per kilowatt from N58.59, while customers in low demand areas were asked to pay N57.52 per kilowatt from from N55.87. The six DisCos approved by NERC for the rate increase are Ikeja Electricity Distribution Company (IKEDC); Port Harcourt Electricity Distribution Company (PHEDC), Jos Electricity Distribution Company (JEDC), Ibadan Electricity Distribution Company (IBEDC); Kano Electricity Distribution Company (KEDC) and Kaduna Electricity Distribution Company (KEDC). According to the NERC, some of the indices taken into account for the tariff increase are inflation, the price of gas, the exchange rate, the rate of inflation in the United States and the available production capacity. The regulator further stated that the indices would be reviewed every six months to update the tariffs with applicable index changes in accordance with the Multi-Year Tariff Order (MYTO). But the Nigerian Electricity Regulatory Commission (NERC) later explained that its recent reviews did not automatically translate into higher electricity tariffs. The clarification followed public outcry over recent reports of tariff increases by electricity distribution companies (DisCos). licensing revenue requirements’ published.’ The electricity market regulator said that where the impact of improved efficiency of operating parameters for individual licensees exceeds the impact of changes in macroeconomic parameters, end users could be reduced, as shown in some fare classes under MYTO 2022. the impact of improved operating metrics efficiency for individual licensees exceeded the impact of changes in macroeconomic metrics, users final rates may be reduced as outlined in certain fare classes under the Multi-Year Rate Order, MYTO 2022.”

The Commission further notified that, in accordance with the Electric Power Sector Reform Act (EPSRA) and other existing sector rules, it will initiate the July 2022 minor revision processes of the MYTO 2022 to consider changes in relevant macroeconomic indices, production capacity and CAPEX. necessary for the evacuation and distribution of the available production capacity in accordance with the rules in force.

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Inadequate attention to power supply by the government has crippled many manufacturing and small businesses in the country.

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Make the process of accessing medical cannabis easier, urges mother of boy with epilepsy https://kepplah.com/make-the-process-of-accessing-medical-cannabis-easier-urges-mother-of-boy-with-epilepsy/ Sat, 11 Jun 2022 09:37:25 +0000 https://kepplah.com/make-the-process-of-accessing-medical-cannabis-easier-urges-mother-of-boy-with-epilepsy/

The mother of a boy with severe epilepsy has urged medical cannabis makers to ease the financial burden on beleaguered families.

Charlotte Caldwell said dozens of families with severe epilepsy are having to pay privately for prescriptions at a time when the cost of living is soaring.

Ms Caldwell and her son Billy, from Castlederg, Co Tyrone, played a leading role in a campaign to win a law change in 2018 allowing some patients to access treatment through the NHS.

However, she told the PA news agency that despite the breakthrough, the road has been difficult for families like hers.

She was speaking on the fourth anniversary of the confiscation of her son’s medical cannabis at Heathrow Airport after he returned from medical treatment in Canada. They had traveled there after their GP was unable to continue prescribing the drug.

It was later returned to him after he fell ill and was treated at Chelsea and Westminster Hospital in London, where his NHS doctor informed the Home Office that Billy’s condition was become deadly.

Charlotte Caldwell and her son Billy, 16, who played a key role in the campaign to change the law to allow the prescription of medical cannabis for certain conditions (Brian Lawless/PA)

(PA wire)

The then Home Secretary, Sajid Javid, allowed the return of medical cannabis and, in November of the same year, amended the law to allow its prescription by specialist doctors under certain conditions.

Ms Caldwell described the process of obtaining a health service-funded prescription for medical cannabis as tedious and said many families had to resort to private healthcare to obtain it or risk the black market .

She said four years after legalisation, there were 1,486 NHS-funded prescriptions for medical cannabis in the UK.



While I am delighted that there is now a pathway to affordable and reliable medical cannabis treatment in the UK, I am saddened that it remains a complex and sometimes opaque process.

Charlotte Caldwell

But she said it is estimated that up to 60 pediatric epilepsy patients cannot get NHS-funded medical cannabis and some would pay up to £2,000 a month to access it through private healthcare .

About 1.4 million people use cannabis on the black market to treat a medical condition.

Ms Caldwell offers her experience to advise families and has made several appeals to the government and medical cannabis manufacturers to facilitate the process.

She said a framework exists but is only available to people aged 18 or under, leaving behind ‘forgotten children’ who require full-time care.

“The Refractory Epilepsy Specialist Clinical Advisory Service (RESCAS) was established in 2020 to support pediatric neurologists when considering medical cannabis (and other new treatments) for refractory epilepsy; his unbiased recommendations are passed on to the patient’s doctor, and it was through this route that Billy reclaimed his NHS funding in October 2020,’ she said, urging that it be extended to all ages.

Ms Caldwell offers her experience to advise families (Brian Lawless/PA)

(PA wire)

Ms. Caldwell is also asking medical cannabis manufacturers to offer their drugs to pediatric epilepsy patients while they go through the RESCAS process.

She told PA: “While I am delighted that there is now a pathway to affordable and reliable medical cannabis treatment in the UK, I am saddened that it remains a complex and sometimes opaque process.

“Four years after Billy’s medication was confiscated from me at Heathrow Airport, I want to share the lessons of my experience with other families, for whom the journey need not be so burdensome complications, grief and enormous personal expense.

“I also call on medical cannabis manufacturers, who are doing so well with private prescriptions, to put their medicine where their mouths are by offering medical cannabis to patients seeking NHS funding.

“It would immediately relieve a huge financial burden facing patients and their families, during which time I hope to help them navigate the complicated approval process.”

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